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Costs and quality of life by disability among people with multiple sclerosis: a register-based study in Sweden
Karolinska Institutet / University of Gothenburg.ORCID-id: 0000-0001-6890-5162
Karolinska Institutet.ORCID-id: 0000-0003-3896-7332
Karolinska Institutet.
Karolinska Institutet / Karolinska University Hospital.
Vise andre og tillknytning
2018 (engelsk)Inngår i: Multiple sclerosis journal - experimental, translational and clinical, E-ISSN 2055-2173, Vol. 4, nr 3, artikkel-id 2055217318783352Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: Population-based estimates of costs of illness and health-related quality of life, by disability levels among people with multiple sclerosis, are lacking.

Objectives: To estimate the annual costs of illness and health-related quality of life, by disability levels, among multiple sclerosis patients, 21-64 years of age.

Methods: Microdata from Swedish nationwide registers were linked to estimate the prevalence-based costs of illness in 2013, including direct costs (prescription drug use and specialised healthcare) and indirect costs (calculated using sick leave and disability pension), and health-related quality of life (estimated from the EQ-5D). Disability level was measured by the Expanded Disability Status Scale (EDSS).

Results: Among 8906 multiple sclerosis patients, EDSS 0.0-3.5 and 7.0-9.5 were associated with mean indirect costs of SEK 117,609 and 461,357, respectively, whereas direct costs were similar between the categories (SEK 117,423 and 102,714, respectively). Prescription drug costs represented 40% of the costs of illness among multiple sclerosis patients with low EDSS, while among patients with high EDSS more than 80% were indirect costs. Among the 1684 individuals who had reported both EQ-5D and EDSS, the lowest health-related quality of life scores were found among those with a high EDSS.

Conclusion: Among people with multiple sclerosis, we confirmed higher costs and lower health-related quality of life in higher disability levels, in particular high indirect costs.

sted, utgiver, år, opplag, sider
2018. Vol. 4, nr 3, artikkel-id 2055217318783352
Emneord [en]
Multiple sclerosis, cost of illness, disability evaluation, disease progression, health-related quality of life, healthcare costs, registries, sick leave
HSV kategori
Identifikatorer
URN: urn:nbn:se:rkh:diva-2611DOI: 10.1177/2055217318783352PubMedID: 30090640OAI: oai:DiVA.org:rkh-2611DiVA, id: diva2:1243160
Forskningsfinansiär
Forte, Swedish Research Council for Health, Working Life and Welfare, 2007-1762Tilgjengelig fra: 2018-08-30 Laget: 2018-08-30 Sist oppdatert: 2018-09-03bibliografisk kontrollert

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