Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • harvard-anglia-ruskin-university
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Unilateral extrapulmonary airway bypass in advanced emphysema
Department of Respiratory Medicine, Royal Brompton and Harefield NHS Trust, London, United Kingdom.
Department of Respiratory Medicine, Royal Brompton and Harefield NHS Trust, London, United Kingdom.
Department of Thoracic Surgery, Royal Brompton and Harefield NHS Trust, London, United Kingdom.
Department of Respiratory Medicine, Royal Brompton and Harefield NHS Trust, London, United Kingdom.
Vise andre og tillknytning
2010 (engelsk)Inngår i: Annals of Thoracic Surgery, ISSN 0003-4975, E-ISSN 1552-6259, Vol. 89, nr 3, s. 899-906Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

BACKGROUND: Gas trapping in emphysema results in resting and dynamic hyperinflation. We tested the hypothesis that a direct connection between the lung parenchyma and the atmosphere could increase expiratory flow and thereby potentially improve dyspnea through the relief of gas trapping.

METHODS: Ex vivo we studied 7 emphysematous lungs and 3 fibrotic lungs (as controls) and measured expiratory flow before and after airway bypass insertion during a forced maneuver in an artificial thorax. Pilot studies were conducted in vivo in 6 patients with advanced emphysema using a size 9 endotracheal tube as a bypass surgically placed through the chest wall into the upper lobe.

RESULTS: In the ex vivo emphysematous lungs the volume expelled during a forced expiratory maneuver increased from 169 to 235 mL (p < 0.05). In the in vivo group 4 patients retained the bypass tube for 3 months or more; total lung capacity was reduced, and the forced expiratory volume in 1 second increased by 23% (mean percent predicted at baseline versus 3 months, 24.4% versus 29.5%).

CONCLUSIONS: An extrapulmonary airway bypass increases expiratory flow in emphysema. This may be a useful approach in hyperinflated patients with homogeneous emphysema.

sted, utgiver, år, opplag, sider
Elsevier, 2010. Vol. 89, nr 3, s. 899-906
Emneord [en]
emphysema
HSV kategori
Identifikatorer
URN: urn:nbn:se:rkh:diva-488DOI: 10.1016/j.athoracsur.2009.10.067OAI: oai:DiVA.org:rkh-488DiVA, id: diva2:606335
Tilgjengelig fra: 2013-02-19 Laget: 2013-02-18 Sist oppdatert: 2019-08-30bibliografisk kontrollert

Open Access i DiVA

Fulltekst mangler i DiVA

Andre lenker

Forlagets fulltekst

Personposter BETA

Björling, Gunilla

Søk i DiVA

Av forfatter/redaktør
Björling, Gunilla
I samme tidsskrift
Annals of Thoracic Surgery

Søk utenfor DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric

doi
urn-nbn
Totalt: 109 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • harvard-anglia-ruskin-university
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf