Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Total and Trimester-Specific Gestational Weight Gain and Offspring Birth and Early Childhood Weight: A Prospective Cohort Study on Monozygotic Twin Mothers and Their Offspring
Karolinska Institutet.ORCID iD: 0000-0002-7295-7341
University of Helsinki, Helsinki, Finland.
Karolinska Institutet / Stockholm County Council.
University of Southern Denmark, Odense, Denmark.
Show others and affiliations
2016 (English)In: Twin Research and Human Genetics, ISSN 1832-4274, E-ISSN 1839-2628, Vol. 19, no 4, 367-76 p.Article in journal (Refereed) Published
Abstract [en]

Gestational weight gain (GWG) has in numerous studies been associated with offspring birth weight (BW) and childhood weight. However, these associations might be explained by genetic confounding as offspring inherit their mother's genetic potential to gain weight. Furthermore, little is known about whether particular periods of pregnancy could influence offspring body weight differently. We therefore aimed to explore total and trimester-specific effects of GWG in monozygotic (MZ) twin mother-pairs on their offspring's BW, weight at 1 year and body mass index (BMI) at 5 and 10 years. MZ twin mothers born 1962-1975 were identified in national Swedish registers, and data on exposure and outcome variables was collected from medical records. We analyzed associations within and between twin pairs. We had complete data on the mothers' GWG and offspring BW for 82 pairs. The results indicated that total, and possibly also second and third trimester GWG were associated with offspring BW within the twin pairs in the fully adjusted model (β = 0.08 z-score units, 95% CI: 0.001, 0.17; β = 1.32 z-score units, 95% CI: -0.29, 2.95; and β = 1.02 z-score units, 95% CI: -0.50, 2.54, respectively). Our findings, although statistically weak, suggested no associations between GWG and offspring weight or BMI during infancy or childhood. Our study suggests that total, and possibly also second and third trimester, GWG are associated with offspring BW when taking shared genetic and environmental factors within twin pairs into account. Larger family-based studies with long follow-up are needed to confirm our findings.

Place, publisher, year, edition, pages
2016. Vol. 19, no 4, 367-76 p.
Keyword [en]
birth weight, childhood body weight, genetics, gestational trimester, gestational weight gain, monozygotic twins
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:rkh:diva-2399DOI: 10.1017/thg.2016.37PubMedID: 27161254OAI: oai:DiVA.org:rkh-2399DiVA: diva2:1095931
Available from: 2017-05-16 Created: 2017-05-16 Last updated: 2017-05-17Bibliographically approved
In thesis
1. Pregnancy weight gain: family studies on the effects on offspring’s body size and blood pressure
Open this publication in new window or tab >>Pregnancy weight gain: family studies on the effects on offspring’s body size and blood pressure
2016 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Introduction: Increasing maternal weight gain during pregnancy, gestational weight gain (GWG), is associated with several adverse outcomes in the child, e.g. high birth weight, childhood overweight and obesity, as well as adult blood pressure (BP). Studies have also shown that specific periods of pregnancy might be more sensitive in terms of influencing these outcomes. However, the aforementioned associations could be explained by genetic and/or environmental factors which are shared between the mother and child. As far as we know, no studies have examined to what extent these genetic and environmental factors explain the variation in GWG.

Aims: The overall aim of this PhD thesis was therefore to investigate the possible associations between GWG and the children’s birth weight and body mass index (BMI) during childhood (study 2), and BP during early adulthood (study 3), while taking environmental and genetic factors shared between the mother and child into account (within the twin/sibling pairs). The current thesis also aimed at exploring how much of the variation in GWG which is determined by genetic (the heritability) and both unique and common environmental factors (study 1).

Methods and Results: Study 1 was a register-based twin study with Swedish female monozygotic (MZ) and dizygotic (DZ) twin pairs with children born 1982-1989 and 1992- 2010. Genetic factors accounted for 43% of the variation in GWG in the first pregnancy (N = 694 twin mother-pairs) and 26% in the second pregnancy (N = 465 twin mother-pairs). Unique environmental factors explained the remaining variation in GWG. Studies 2 and 3 were both prospective cohort studies, where study 2 was based on a data-collection of Swedish MZ twin mothers born 1962 to 1975 and their children (N = 82 twin mother-pairs), and study 3 was register-based and included Swedish male sibling pairs born 1982-1989 (N = 4908 brother pairs). In study 2, the results indicated that total, and possibly also second and third trimester weight gain, were associated with birth weight in the offspring within the twin pairs in the fully adjusted model. In terms of GWG and offspring weight and BMI during infancy and childhood, no associations were found. In study 3, no significant associations were found between GWG and systolic BP, or diastolic BP, or the offspring’s risk of hypertension, neither within nor between the sibling pairs.

Conclusions: This thesis shows that the total GWG, and specifically weight gain during the second and third trimester, seem to be positively associated with offspring birth weight, but no effects were seen for BMI during infancy and childhood. However, due to the limited sample size, this requires further investigation. Moreover, no association was found between total GWG and the male sibling pairs’ BP at the age of 18 years. The variation in GWG seems to be largely explained by the mother’s unique environment during pregnancy and to a smaller degree by genetic factors.

Place, publisher, year, edition, pages
Stockholm: Karolinska Institutet, 2016
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:rkh:diva-2402 (URN)978-91-7676-355-1 (ISBN)
Available from: 2017-05-17 Created: 2017-05-17 Last updated: 2017-05-17Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Authority records BETA

Scheers Andersson, Elina

Search in DiVA

By author/editor
Scheers Andersson, Elina
In the same journal
Twin Research and Human Genetics
Public Health, Global Health, Social Medicine and Epidemiology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 4 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf