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Cognitive function predicts work disability among multiple sclerosis patients
Karolinska Institutet.ORCID iD: 0000-0003-3896-7332
The Swedish Red Cross University College, Department of Health Sciences. Karolinska Institutet.ORCID iD: 0000-0001-6138-6427
Karolinska Institutet.
Karolinska Institutet / Karolinska University Hospital.
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2019 (English)In: Multiple sclerosis journal - experimental, translational and clinical, ISSN 2055-2173, Vol. 5, no 1, article id 2055217318822134Article in journal (Refereed) Published
Abstract [en]

Background: In multiple sclerosis various aspects of cognitive function can be detrimentally affected. More than that, patients´ employment and social functioning is likely to be impacted.

Objective: To determine whether work disability among multiple sclerosis patients could be predicted by the symbol digit modalities test.

Methods: A register-based cohort study was conducted. Individual data on work disability, operationalised as annual net days of sickness absence and/or disability pension were retrieved at baseline, when the symbol digit modalities test was performed, after one-year and 3-year follow-up for 903 multiple sclerosis patients. The incidence rate ratios for work disability were calculated with general estimating equations using a negative binomial distribution and were adjusted for gender, age, educational level, family composition, type of living area and physical disability.

Results: After one year of follow-up, the patients in the lowest symbol digit modalities test quartile were estimated to have a 73% higher rate of work disability when compared to the patients in the highest symbol digit modalities test quartile (incidence rate ratio 1.73, 95% confidence interval 1.42‒2.10). This estimate after 3-year follow-up was similar (incidence rate ratio 1.68, 95% confidence interval 1.40‒2.02).

Conclusion: Cognitive function is to a high extent associated with multiple sclerosis patients' future work disability, even after adjusting for other factors.

Place, publisher, year, edition, pages
2019. Vol. 5, no 1, article id 2055217318822134
Keywords [en]
Multiple sclerosis, cognition, employment, prognosis, socioeconomic factors, work
National Category
General Practice
Identifiers
URN: urn:nbn:se:rkh:diva-2750DOI: 10.1177/2055217318822134PubMedID: 30729025OAI: oai:DiVA.org:rkh-2750DiVA, id: diva2:1291375
Funder
Forte, Swedish Research Council for Health, Working Life and WelfareAvailable from: 2019-02-25 Created: 2019-02-25 Last updated: 2019-02-27Bibliographically approved

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Tinghög, Petter

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