Cranial skeletal lesions as well as linear enamel hypoplasias were investigated in an Early Iron Age (0–260 A.D.) population from Sweden. The analyses included the study of maxillary- and frontal sinusitis, cribra orbitalia and enamel hypoplasias in order to investigate nutritional and environmental related stress as well as possible relation to oral health. A majority of both subadult and adult individuals exhibited maxillary sinusitis as well as cribra orbitalia. In contrast, linear enamel hypoplasias were not frequently noted, although, the highest frequencies were found among the subadult individuals. In seven cases (12.7%) there was a clear correlation between a periapical lesions and maxillary sinusitis. A significant correlation between maxillary sinusitis and frontal sinusitis was found among adult individuals. Sixty-eight percent of the adults showed lesions in both these regions. The least common combination in adults was cribra orbitalia and enamel hypoplasias where 7.7% only exhibited lesions in both these regions. The significantly higher incidence of this combination among subadults at Smörkullen suggests that this may have been related to life threatening conditions. Overall, the result showed that the individuals at Smörkullen foremost suffered from upper respiratory diseases as well as nutritional deficiency.