rkh.sePublications from Swedish Red Cross University
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • harvard-anglia-ruskin-university
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Costs of illness progression for different multiple sclerosis phenotypes: a population-based study in Sweden
Karolinska Institutet; University of Gothenburg.ORCID iD: 0000-0001-6890-5162
Karolinska Institutet.ORCID iD: 0000-0003-3896-7332
Karolinska Institutet.ORCID iD: 0000-0003-4150-4275
Karolinska Institutet.
Show others and affiliations
2019 (English)In: Multiple Sclerosis Journal, Experimental, Translational and Clinical, E-ISSN 2055-2173, Vol. 5, no 2, article id 2055217319858383Article in journal (Refereed) Published
Abstract [en]

Background

Population-based estimates of costs of illness and health-related quality of life, by disability levels among people with multiple sclerosis, are lacking.

Objectives

To estimate the annual costs of illness and health-related quality of life, by disability levels, among multiple sclerosis patients, 21–64 years of age.

Methods

Microdata from Swedish nationwide registers were linked to estimate the prevalence-based costs of illness in 2013, including direct costs (prescription drug use and specialised healthcare) and indirect costs (calculated using sick leave and disability pension), and health-related quality of life (estimated from the EQ-5D). Disability level was measured by the Expanded Disability Status Scale (EDSS).

Results

Among 8906 multiple sclerosis patients, EDSS 0.0–3.5 and 7.0–9.5 were associated with mean indirect costs of SEK 117,609 and 461,357, respectively, whereas direct costs were similar between the categories (SEK 117,423 and 102,714, respectively). Prescription drug costs represented 40% of the costs of illness among multiple sclerosis patients with low EDSS, while among patients with high EDSS more than 80% were indirect costs. Among the 1684 individuals who had reported both EQ-5D and EDSS, the lowest health-related quality of life scores were found among those with a high EDSS.

Conclusion

Among people with multiple sclerosis, we confirmed higher costs and lower health-related quality of life in higher disability levels, in particular high indirect costs.

Place, publisher, year, edition, pages
Sage Publications, 2019. Vol. 5, no 2, article id 2055217319858383
Keywords [en]
Multiple sclerosis, cost of illness, healthcare costs, registries, sick leave, health-related quality of life, disability evaluation, disease progression
National Category
Health Care Service and Management, Health Policy and Services and Health Economy Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:rkh:diva-3013DOI: 10.1177/2055217319858383PubMedID: 31285832OAI: oai:DiVA.org:rkh-3013DiVA, id: diva2:1342010
Available from: 2019-08-12 Created: 2019-08-12 Last updated: 2021-09-09Bibliographically approved

Open Access in DiVA

fulltext(788 kB)297 downloads
File information
File name FULLTEXT01.pdfFile size 788 kBChecksum SHA-512
5e3464c808300bf7eaf8fa70d242cc13d1c5ad9d111665b87e941b84a7a895d943de3ac3e8ce1a19d6a3f032b317bb3654af19a272fe6f1ecf60639ce96b1ec4
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records

Tinghög, Petter

Search in DiVA

By author/editor
Gyllensten, HannaKavaliunas, AndriusMurley, ChantelleTinghög, Petter
By organisation
Department of Health Sciences
In the same journal
Multiple Sclerosis Journal, Experimental, Translational and Clinical
Health Care Service and Management, Health Policy and Services and Health EconomyPublic Health, Global Health, Social Medicine and Epidemiology

Search outside of DiVA

GoogleGoogle Scholar
Total: 297 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 574 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • harvard-anglia-ruskin-university
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf