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Acute resveratrol supplementation in coronary artery disease: towards patient stratification
The Swedish Red Cross University College, Department of Health Sciences. Manchester Metropolitan University, UK.
Manchester Metropolitan University, UK / KU Leuven, Belgium.
Manchester Metropolitan University, UK / Lithuanian Sports University, Lithuania.
KU Leuven, Belgium.
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2019 (English)In: Scandinavian Cardiovascular Journal, ISSN 1401-7431, E-ISSN 1651-2006, p. 1-20Article in journal (Refereed) Epub ahead of print
Abstract [en]

OBJECTIVE: Resveratrol (RV) is a polyphenol with antioxidant, anti-inflammatory and cardio-protective properties. Our objective was to investigate whether acute supplementation with high doses of RV would improve flow-mediated dilation (FMD) and oxygen consumption (VO2) kinetics in older coronary artery disease (CAD) patients.

DESIGN: We employed a placebo-controlled, single-blind, crossover design in which ten participants (aged 66.6 ± 7.8 years) received either RV or placebo (330 mg, 3x day-1) during three consecutive days plus additional 330 mg in the morning of the fourth day with a seven-day wash-out period in-between. On the fourth day, FMD of the brachial artery and VO2 on-kinetics were determined. Results; RV improved FMD in patients who had undergone coronary artery bypass grafting (CABG; -1.4 vs. 5.0%; p = 0.004), but not in those who had undergone percutaneous coronary intervention (PCI; 4.2 vs. -0.2%; NS).

CONCLUSION: Acute high dose supplementation with RV improved FMD in patients after CABG surgery but impaired FMD in patients who underwent PCI. The revascularization method-related differential effects of RV may be due to its direct effects on endothelial-dependent dilator responses. Our findings have important implications for personalized treatment and stratification of older CAD patients.

Place, publisher, year, edition, pages
2019. p. 1-20
Keywords [en]
Aging, Antioxidant, Endothelial Dysfunction, Oxygen Uptake
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:rkh:diva-3018DOI: 10.1080/14017431.2019.1657584PubMedID: 31429599OAI: oai:DiVA.org:rkh-3018DiVA, id: diva2:1345302
Available from: 2019-08-23 Created: 2019-08-23 Last updated: 2019-08-23Bibliographically approved

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Díaz, Miguel

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