Background: Health-related infections (VRI) have a negative impact on public health and cause suffering for the patient and costs to society. Problematization: VRI is a patient safety problem and risks affecting both patient and nurse. Aim: The aim of the study was to describe nurses' experiences of preventive work against healthcare-associated infections. Method: A literature review based on 11 articles based on a qualitative method was analyzed through thematization. Results: The results showed that the nurses had varied attitudes to hygiene and prevention of infections. Some experienced the need for training to better prevent infections, while others showed different considerations for maintaining hygiene in the workplace, depending on previous experience and the opportunities offered by the nursing environment. The nurses experienced a challenging work environment with a high workload and a lack of work motivation. They wanted their nursing environment to be upgraded to increase the chances of infection prevention. Conclusion: One conclusion and implication were that nurses need to take more consideration to each patient's individual need in the prevention work against infections. Continued research can examine patients 'experiences of nurses' work towards VRI.