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Early bioavailability in day surgery: A comparison between orally, rectally, and intravenously administered paracetamol
Department of Cardiothoracic Surgery and Anaesthesiology, Karolinska University Hospital, Stockholm.
2005 (English)In: Ambulatory Surgery, ISSN 0966-6532, ISSN 0966-6532, Vol. 12, no 1, 27-30 p.Article in journal (Refereed) Published
Abstract [en]

Purpose: Compare early bioavailability of rectal, effervescent oral, and i.v. paracetamol.

Scope:Five groups of N = 7 patients received 1 or 2 g paracetamol orally or rectally or 1 g i.v. immediately after day surgery. Paracetamol concentrations taken after 20, 40 and 80 min. Median plasma paracetamol concentrations for 1 versus 2 g effervescents were 78 (25–114) versus 108 (95–146) μmol L−1 at 80 min and 16 (9–30) versus 17 (10–30) μmol L−1 for 1 versus 2 g suppositories. Paracetamol i.v. gave median 97 (77–135) μmol L−1 after 40 min.

Conclusion: Only intravenously and 2 g effervescent paracetamol gave therapeutic concentrations during the period studied.

Place, publisher, year, edition, pages
2005. Vol. 12, no 1, 27-30 p.
Keyword [en]
day surgery, postoperative analgesia, paracetamol, suppositories, effervescent tablets
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:rkh:diva-360DOI: 10.1016/j.ambsur.2005.02.001OAI: oai:DiVA.org:rkh-360DiVA: diva2:552708
Available from: 2012-09-15 Created: 2012-09-15 Last updated: 2013-11-05Bibliographically approved

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