Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Decline in blood pressure over time and risk of dementia: a longitudinal study from the Kungsholmen project
2004 (English)In: Stroke, ISSN 0039-2499, E-ISSN 1524-4628, Vol. 35, no 8, 1810-1815 p.Article in journal (Refereed) Published
Abstract [en]

Background and Purpose—Low blood pressure has been related to an increased risk of dementia. We sought to verify blood pressure variations before and after a dementia diagnosis and to relate blood pressure decline to subsequent Alzheimer disease and dementia.

Methods—A community dementia-free cohort aged _75 years (n_947) underwent follow-up examinations twice over a period of 6 years to detect dementia cases (Diagnostic and Statistical Manual of Mental Disorders, 3rd edition, revised [DSM-III-R] criteria, n_304). Blood pressure variation before and after dementia diagnosis was verified with linear mixed-effects models. Using the dementia-free cohort identified at first follow-up (n_719), the association between blood pressure decline from baseline to first follow-up and subsequent risk of dementia was examined.

Results—Blood pressure markedly decreased over 3 years before dementia diagnosis and afterward, whereas no substantial decline was present 3 to 6 years before the diagnosis. However, among subjects with baseline systolic pressure _160 mm Hg, systolic pressure decline _15 mm Hg occurring 3 to 6 years before diagnosis was associated with relative risks (95% CI) of 3.1 (1.3 to 7.0) for Alzheimer disease and 3.1 (1.5 to 6.3) for dementia. There was a dose–response relationship between systolic pressure decline and dementia risk in subjects with vascular disease.

Conclusions—Blood pressure starts to decrease only 3 years before dementia diagnosis and continues to decline afterward. A greater decline in systolic pressure occurring 3 to 6 years before diagnosis is associated with an increased risk of dementia only in older people with already low blood pressure or affected by vascular disorders.

Place, publisher, year, edition, pages
American Stroke Association , 2004. Vol. 35, no 8, 1810-1815 p.
Keyword [en]
alzheimer disease, blood pressure, dementia, epidemiology
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:rkh:diva-571DOI: 10.1161/01.STR.0000133128.42462.efPubMedID: 15232128OAI: oai:DiVA.org:rkh-571DiVA: diva2:609065
Available from: 2013-03-04 Created: 2013-03-04 Last updated: 2016-04-19Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMedhttp://stroke.ahajournals.org/content/35/8/1810.long

Search in DiVA

By author/editor
von Strauss, Eva
In the same journal
Stroke
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 59 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf