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Impact of anxiety and depression on respiratory symptoms
Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala University; Department of Medical Sciences, Respiratory Medicine and Allergology, Uppsala University.ORCID iD: 0000-0002-3944-8633
Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala University.
Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala University.
Surgical and Perioperative sciences, Department of Surgery, Umeå University.
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2014 (English)In: Respiratory Medicine, ISSN 0954-6111, E-ISSN 1532-3064, Vol. 198, no 11, 1594-1600 p.Article in journal (Refereed) Published
Abstract [en]

Psychological factors such as anxiety and depression are prevalent in patients with asthma. The purpose of this study was to investigate the relationship between respiratory symptoms and psychological status and to estimate the importance of psychological status in comparison with other factors that are known to be associated with respiratory symptoms.

This study included 2270 subjects aged 20–44 (52% female) from Sweden, Iceland, and Norway. Each participant underwent a clinical interview including questions on respiratory symptoms. Spirometry and methacholine challenge were performed. Symptoms of depression and anxiety were measured using the Hospital Anxiety and Depression Scale (HADS).

Eighty-two percent of the subjects reported no anxiety or depression whatsoever, 11% reported anxiety, 2.5% depression and 4% reported both anxiety and depression. All respiratory symptoms, such as wheezing, breathlessness and nightly symptoms, were more common, at a statistically significant level, in participants who had depression and anxiety, even after adjusting for confounders (ORs 1.33 – 1.94). The HADS score was the most important determinant for nightly symptoms and attacks of breathlessness when at rest whereas bronchial responsiveness was the most important determinant for wheezing, and breathlessness when wheezing. The probability of respiratory symptoms related to HADS score increased with increasing HADS score for all respiratory symptoms.

In conclusion, there is a strong association between respiratory symptoms and psychological status. There is therefore a need for interventional studies designed to improve depression and anxiety in patients with respiratory symptoms.

Place, publisher, year, edition, pages
Elsevier, 2014. Vol. 198, no 11, 1594-1600 p.
Keyword [en]
asthma, anxiety, depression
National Category
Respiratory Medicine and Allergy Medical and Health Sciences
Identifiers
URN: urn:nbn:se:rkh:diva-1006DOI: 10.1016/j.rmed.2014.09.007PubMedID: 25282543OAI: oai:DiVA.org:rkh-1006DiVA: diva2:744309
Available from: 2014-09-08 Created: 2014-09-08 Last updated: 2017-05-17Bibliographically approved

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CiteExportLink to record
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