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Effects of proinsulin C-peptide on oxygen transport, uptake and utilization in insulinopenic diabetic subjects: a review
Uppsala universitet, Integrativ Fysiologi.
Uppsala universitet, Integrativ Fysiologi.ORCID iD: 0000-0003-4092-2854
2009 (English)In: Oxygen Transport to Tissue XXX / [ed] Liss, Per, Hansell, Peter, Bruley, Duane F., New York: Springer, 2009, Vol. 645, 193-198 p.Conference paper, (Refereed)
Abstract [en]

Exogenous C-peptide administration has beneficial effects in many of the tissues commonly affected by diabetic complications. Diabetes-induced circulatory impairments such as decreased blood flow are prevented by C-peptide, possibly via Ca2+-mediated effects on nitric oxide release. C-peptide also improves diabetes-induced erythrocyte deformability, which likely improves oxygen availability and uptake in affected tissues. Furthermore, C-peptide prevents diabetic neuropathy via improvements of endoneural blood flow and by preventing axonal swelling. In the kidney, C-peptide normalizes the diabetes-induced increase in oxygen consumption via inhibition of the Na+/K+-ATPase. Surprisingly, C-peptide has also been shown to prevent complications in patients with type II diabetes. Taken together, these results may indicate that C-peptide treatment has the potential to reduce the prevalence of diabetic complications. In this paper, the current knowledge regarding these beneficial effects of C-peptide administered to diabetic subjects will be reviewed briefly.

Place, publisher, year, edition, pages
New York: Springer, 2009. Vol. 645, 193-198 p.
Series
Advances in Experimental Medicine and Biology, ISSN 0065-2598 ; 645
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:rkh:diva-1090DOI: 10.1007/978-0-387-85998-9_30PubMedID: 19227471ISBN: 978-0-387-85997-2 (print)ISBN: 978-0-387-85998-9 (print)OAI: oai:DiVA.org:rkh-1090DiVA: diva2:750776
Conference
35th Annual Conference of the International-Society-on-Oxygen-Transport-to-Tissue Uppsala, SWEDEN, 2007.
Available from: 2009-05-06 Created: 2014-09-26 Last updated: 2015-08-10Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
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