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Cohort Effects in the Prevalence and Survival of People with Dementia in a Rural Area in Northern Sweden
Aging Research Center (ARC), Karolinska Institutet and Stockholm University / Uppsala University.
Aging Research Center (ARC), Karolinska Institutet and Stockholm University / University of Gävle.
Aging Research Center (ARC), Karolinska Institutet and Stockholm University.
Aging Research Center (ARC), Karolinska Institutet and Stockholm University.
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2015 (English)In: Journal of Alzheimer's Disease, ISSN 1387-2877, E-ISSN 1875-8908, Vol. 50, no 2, 387-396 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Recent studies suggest that trends in cardiovascular risk may result in a decrease in age-specific prevalence of dementia. Studies in rural areas are rare.

OBJECTIVES: To study cohort effects in dementia prevalence and survival of people with dementia in a Swedish rural area.

METHODS: Participants were from the 1995-1998 Nordanstig Project (NP) (n = 303) and the 2001-2003 Swedish National study on Aging and Care in Nordanstig (SNAC-N) (n = 384). Overall 6-year dementia prevalence and mortality in NP and SNAC-N were compared for people 78 years and older. Logistic regression analyses were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for dementia occurrence using the NP study population as the reference group. Cox regression models were used to analyze time to death.

RESULTS: The crude prevalence of dementia was 21.8% in NP and 17.4% in SNAC-N. When the NP cohort was used as the reference group, the age- and gender-adjusted OR of dementia was 0.71 (95% CI 0.48-1.04) in SNAC-N; the OR was 0.47 (0.24-0.90) for men and 0.88 (0.54-1.44) for women. In the extended model, the OR of dementia was significantly lower in SNAC-N than in the NP cohort as a whole (0.63; 0.39-0.99) and in men (0.34; 0.15-0.79), but not in women (0.81; 0.46-1.44). The Cox regression models indicated that the hazard ratio of dying was lower in the SNAC-N than NP population.

CONCLUSIONS: Trends toward a lower prevalence of dementia in high-income countries seem to be evident in this Swedish rural area, at least in men.

Place, publisher, year, edition, pages
2015. Vol. 50, no 2, 387-396 p.
Keyword [en]
Dementia; mortality; prevalence; rural population
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:rkh:diva-1987DOI: 10.3233/JAD-150708PubMedID: 26639970OAI: oai:DiVA.org:rkh-1987DiVA: diva2:886231
Available from: 2015-12-22 Created: 2015-12-18 Last updated: 2016-04-19Bibliographically approved

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