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  • 1.
    Iwarzon, Marie
    et al.
    Karolinska Institutet, Karolinska University Hospital.
    Gardulf, Ann
    Red Cross University College of Nursing. Karolinska Institutet, Karolinska University Hospital.
    Lindberg, Greger
    Karolinska Institutet, Karolinska University Hospital.
    Functional status, health-related quality of life and symptom severity in patients with chronic intestinal pseudo-obstruction and enteric dysmotility2009In: Scandinavian Journal of Gastroenterology, ISSN 0036-5521, E-ISSN 1502-7708, Vol. 44, no 6, p. 700-707Article in journal (Refereed)
    Abstract [en]

    Objective. To investigate whether patients with chronic intestinal pseudo-obstruction (CIP) differ from those with enteric dysmotility (ED) regarding self-reported measures of functional status, health-related quality of life (HRQoL) and gastrointestinal symptoms. Material and methods. The study comprised 28 patients with CIP (median age 48, range 28-80 years) and 26 with ED (median age 50, range 20-75 years). Three self-administered questionnaires were used: the Sickness Impact Profile (SIP), the Swedish HRQoL Questionnaire (SWED-QUAL) and the Gastrointestinal Symptom Rating Scale (GSRS). Results. Patients with CIP reported significantly greater functional impairment in the aggregated physical dimension of SIP (15.4 SD 19.7) than did patients with ED (5.0 SD 7.2, p0.01). They also reported significantly poorer general health (SWED-QUAL) (28.0 SD 20.8) compared to those with ED (44.8 SD 25.2, p 0.01). Symptom severity correlated with several measures of HRQoL and functional status in patients with CIP but abdominal pain severity was the only independent predictor of HRQoL. Abdominal pain alone explained between 21% and 67% of the variance in SWED-QUAL subscales. Likewise, the severity of indigestion symptoms among patients with CIP explained 20-24% of the variance in the SIP subscales, emotional behaviour and work. Much less correlation between symptom severity and functional impairment or HRQoL was found in patients with ED. We found no difference in symptom severity (GSRS) between the two groups. Conclusions. Patients with CIP reported a greater impairment of functional status and HRQoL than did patients with ED. Symptom severity had a stronger influence on functional status and HRQoL in patients with CIP.

  • 2.
    Janczewska, I.
    et al.
    Department of Clinical Sciences, Karolinska Institutet, Division of Internal Medicine Danderyd Hospital, Stockholm.
    Kapraali, M.
    Department of Clinical Sciences, Karolinska Institutet, Division of Internal Medicine Danderyd Hospital, Stockholm.
    Saboonchi, Fredrik
    Sophiahemmet University College, Stockholm.
    Nekzada, Q.
    Department of Clinical Sciences, Karolinska Institutet, Division of Internal Medicine Danderyd Hospital, Stockholm.
    Wessulv, Å.
    Department of Clinical Sciences, Karolinska Institutet, Division of Internal Medicine Danderyd Hospital, Stockholm.
    Khoshkar, J.
    Department of Clinical Sciences, Karolinska Institutet, Division of Internal Medicine Danderyd Hospital, Stockholm.
    Marouf, F.
    Department of Clinical Sciences, Karolinska Institutet, Division of Internal Medicine Danderyd Hospital, Stockholm.
    Gorsetman, J.
    Department of Clinical Sciences, Karolinska Institutet, Division of Internal Medicine Danderyd Hospital, Stockholm.
    Risberg, D.
    Department of Clinical Sciences, Karolinska Institutet, Division of Internal Medicine Danderyd Hospital, Stockholm.
    Lissing, M.
    Department of Clinical Sciences, Karolinska Institutet, Division of Internal Medicine Danderyd Hospital, Stockholm.
    Wirström, G.
    Division of Medicine, Ersta Hospital, Stockholm.
    Sandstedt, B.
    Karolinska Institutet, Department of Pathology, Danderyd Hospital, Stockholm.
    Clinical application of the multigene analysis test in discriminating between ulcerative colitis and Crohn’s disease: A retrospective study2012In: Scandinavian Journal of Gastroenterology, ISSN 0036-5521, E-ISSN 1502-7708, Vol. 47, no 2, p. 162-169Article in journal (Refereed)
    Abstract [en]

    Methods.The newly described – multigene analysis test(DiBiCol) identifying 7 inflammatory bowel disease (IBD)-specific genes incolonic mucosal biopsy differentiating between ulcerative colitis (UC) and Crohn's disease (CD) with active inflammation – is a new addition to existingmethods with a higher stated sensitivity and specificity. Method biopsymaterial from 78 patients with a complicated course diagnosed as most probably UC in 38, CD in 18 and inflammatory bowel disease unclassified (IBDU) in 22 were investigated by DiBiCol. Results. DiBiCol showed a pattern consistent with CD in 13 patients with UC and led to change of diagnosis in 3 patients and a strong suggestion of CD in 8 patients. A total of 2 patients remained as UC. DiBiCol showed a pattern of UC in 4 patients of 18 with CD leading to a changing of diagnosis to UC in 3 patients, but the fourth remained as CD. In 22 patients with IBDU DiBiCol showed a pattern consistent with UC in 7 cases and with CD in 13 cases. A new evaluation 1 year after the DiBiCol allowed the assessment of clinical diagnosis in 10 patients confirmed in 9 of 10 patients by DiBiCol. In patients with acute flare of colitis the clinical diagnosis corresponded in 10 of 12 UC and in 5 of 6 CD cases. Summary. Adoptingthe DiBiCol test led to a change of the primary diagnosis in a significant number of patients with the initial diagnosis of UC and CD and suggested aclinically probable diagnosis in most of the patients with IBDU and in those with an acute flare of colitis.

  • 3.
    Oxelmark, Lena
    et al.
    Karolinska Institutet / Sophiahemmet högskola.
    Hillerås, Pernilla
    Karolinska Institutet / Sophiahemmet högskola.
    Dignass, Axel
    University clinic Charité, Berlin, Germany.
    Mössner, Joachim
    University Clinic, Leipzig, Germany.
    Schreiber, Stefan
    University clinic, Kiel, Germany.
    Kruis, Wolfgang
    Evangelisches Krankenhaus Kalk, Cologne, Germany.
    Löfberg, Robert
    Karolinska Institutet / Sophiahemmet högskola.
    Quality of life in patients with active ulcerative colitis treated with selective leukocyte apheresis2007In: Scandinavian Journal of Gastroenterology, ISSN 0036-5521, E-ISSN 1502-7708, Vol. 42, no 3, p. 406-407Article in journal (Other academic)
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