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  • 1.
    Craftman, Åsa Gransjön
    et al.
    Sophiahemmet University; Aging Research Center (ARC), Karolinska Institutet.
    Johnell, Kristina
    Aging Research Center (ARC), Karolinska Institutet.
    Fastbom, Johan
    Aging Research Center (ARC), Karolinska Institutet.
    Westerbotn, Margareta
    Department of Research, Education, Development and Innovation, Education Center, SÖS.
    von Strauss, Eva
    Röda Korsets Högskola, Avdelningen Medicin och Folkhälsa. Aging Research Center (ARC), Karolinska Institutet.
    Time trends in 20 years of medication use in older adults: Findings from three elderly cohorts in Stockholm, Sweden.2015Ingår i: Archives of gerontology and geriatrics (Print), ISSN 0167-4943, E-ISSN 1872-6976, Vol. 63, s. 28-35Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    New drugs and expanded drug indications are constantly being introduced. Welfare states strive to provide equity in drug treatment for all of its citizens and todaýs healthcare systems spend financial resources on drugs for the elderly in a higher rate than for any other age group. Drug utilization in elderly persons has an impact in health and wellbeing in older people.

    THE PURPOSE OF THE RESEARCH: It was to describe the changes in medication use including people aged 78 years and over regardless of residence and other characteristics over 20 years.

    MATERIALS AND METHODS: The study population consisted of 4304 participants in three population-based cross-sectional surveys conducted in the Kungsholmen area of central Stockholm, Sweden. The participant's current drug utilization was reviewed by physicians following standardized protocols. Data were statistical analyzed. Logistic regression models was used to estimate odds ratios and 95% confidence intervals for use of analgesics and psychotropic drugs in the cohorts of 2001 and 2007, controlling for age, gender, education and cognition.

    THE PRINCIPAL RESULTS AND MAJOR CONCLUSIONS: Results shows that the prevalence of medication use and polypharmacy in older adults has increased dramatically the late 1980s to the 2000s in central Stockholm, Sweden. In particular, the use of analgesics increased significantly, while some drug groups decreased, i.e., antipsychotics. Women used more medication than men in all three cohorts. Older adults living in service buildings used the largest amount of drugs in 1987, whereas those living in institutions were the most frequent users in 2001 and 2007.

  • 2.
    Ericsson, Kjerstin
    et al.
    Karolinska Institutet / Äldrecentrum, Stockholm.
    Hillerås, Pernilla
    Karolinska Institutet / Äldrecentrum, Stockholm.
    Holmén, Karin
    Karolinska Institutet / Äldrecentrum, Stockholm.
    Jorm, Anthony
    Australian National University, Canberra, Australia.
    Forssell, Lars G.
    Karolinska Institutet.
    Almkvist, Ove
    Karolinska Institutet / Äldrecentrum, Stockholm.
    Rönnberg, Lisa
    Karolinska Institutet.
    Winblad, Bengt
    Karolinska Institutet / Äldrecentrum, Stockholm.
    The short human figure drawing scale for evaluation of suspect cognitive dysfunction in old age1994Ingår i: Archives of gerontology and geriatrics (Print), ISSN 0167-4943, E-ISSN 1872-6976, Vol. 19, nr 3, s. 243-251Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Human figure drawings have been widely used to assess cognitive development in children. In the present study, free-hand human figure drawings were examined for 62 demented patients, and 60 normal elderly subjects. The drawings were scored for 53 body details using a method derived from work with children. A short scale of 15 details was developed by selecting body details with high item-total correlations which are simple to score even for untrained staff. This short scale had excellent interscorer and test-retest reliability and excellent concurrent validity as well. It correlated highly with the Mini-Mental State Examination, a commonly used screening test for dementia. The short scale discriminated demented and non-demented subjects and different levels of dementia severity as graded by the Clinical Dementia Rating Scale. However, no differences were observed between Alzheimer patients and patients with vascular dementia concerning presence of details in human figure drawings.

  • 3.
    Sjölund, Britt-Marie
    et al.
    Aging Research Center (ARC), Karolinska Institutet-Stockholm University.
    Wimo, Anders
    Aging Research Center (ARC), Karolinska Institutet-Stockholm University.
    Qiu, Chengxuan
    Aging Research Center (ARC), Karolinska Institutet-Stockholm University.
    Engström, Maria
    University of Gävle.
    von Strauss, Eva
    Röda Korsets Högskola. Aging Research Center (ARC), Karolinska Institutet-Stockholm University.
    Time trends in prevalence of activities of daily living (ADL) disability and survival: Comparing two populations (aged 78+ years) living in a rural area in Sweden2014Ingår i: Archives of gerontology and geriatrics (Print), ISSN 0167-4943, E-ISSN 1872-6976, Vol. 58, nr 3, s. 370-375Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The aim was to study time trends in prevalence of disability in ADL and survival among men and women 78 years and older comparing two cohorts. The study was a time trend study based on two population-based community cohorts, the Nordanstig Project (NP), collected 1995–1998 and the Swedish National Study on Aging and Care in Nordanstig (SNAC-N), collected 2001–2003. The participants were people aged 78 years and older from the NP cohort (N = 303) and from the SNAC-N cohort (N = 406). All were clinically examined by physicians and nurses using standardized protocols. Disability was defined as a need for assistance in one or more ADL activities. The prevalence of disability and survival were compared using logistic and Cox models. The prevalence of ADL disability was stable for men, while women became more disabled in ADL during the time period, OR 2.36 (1.12–4.94). There was no significant difference in survival time between the cohorts in either ADL disabled persons or non-disabled persons. There was a tendency for increased survival for non-disabled persons in SNAC-N compared with NP, although not significant; this was particularly true for women. In general, women survived longer than men did regardless of whether they were ADL disabled or not. The time trends for ADL disability found in the study show that ADL disability had increased in women but not in men. More studies are needed to identify risk factors for ADL disability with a view to preventing it in time.

  • 4.
    Westerbotn, Margareta
    et al.
    Sophiahemmet högskola / Karolinska Institutet / Äldrecentrum, Stockholm.
    Agüero-Torres, Hedda
    Karolinska Institutet / Äldrecentrum, Stockholm.
    Fastbom, Johan
    Karolinska Institutet / Äldrecentrum, Stockholm.
    Hillerås, Pernilla
    Sophiahemmet / Karolinska Institutet / Äldrecentrum, Stockholm.
    A population-based study on well-being in the very old: the role of cardiovascular diseases and drugs2005Ingår i: Archives of gerontology and geriatrics (Print), ISSN 0167-4943, E-ISSN 1872-6976, Vol. 40, nr 3, s. 287-297Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Cardiovascular diseases constitute the most common health problems in very old people. Consequently, cardiovascular drugs are the medicines that are most frequently used by elderly subjects. Although many studies have examined the physiological effect and adverse reactions of these drugs, knowledge on their effect on emotional well-being is missing. The present study aims to examine the association between cardiovascular diseases and their medical treatment on the emotional well-being of very old people. We investigated a representative group of elderly subjects gathered from a population-based study (n=235). Participants were 84 years or older and cognitively intact (mini-mental state examination (MMSE) > or =24 points). Well-being was assessed with the positive and negative affect schedule (PANAS), measuring different mood categories. Cardiovascular diseases were diagnosed following the International Classification of Diseases. In this population the prevalence of cardiovascular diseases was high (62%). Multivariate regression analysis showed that while being affected by a cardiovascular disease did not affect the emotional well-being of the subjects (PANAS-PA, p=0.171; PANAS-NA, p=0.209), the use of some cardiovascular drugs showed an association. Cardiac glycosides (p=0.006) and nitrates (p=0.008) were associated with increased negative feelings. Due to high prevalence of cardiovascular diseases and use of cardiovascular medicines, this finding has relevance on the quality of life of elderly people. However, due to the nature of this study we cannot assess cause-effect relationship of this positive association. Therefore, the present findings suggest that there is a need for clinical studies in this increasing and limited studied age group.

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