Background: In the end-of-life stage, spiritual needs may become particularly significant and constitute a central part of person-centered palliative care. Despite this, there is a risk that spiritual care is overshadowed by physical care in clinical practice. Aim: The aim of the study was to explore nurses’ experiences of meeting the spiritual needs of patients at the end of life. Method: The study was conducted as a general literature study with a qualitative approach and was based on ten scientific original articles. Literature research was conducted in CINAHL and PubMed databases. The included articles were quality appraised and analyzed using qualitative content analysis based on Graneheim and Lundman. Results: The findings showed that nurses’ experiences were characterized by both opportunities and limitations in meeting patients’ spiritual needs. Two Categories were identified: Active presence enables support for faith and religious practices at the end of life and Limited resources affect the ability to meet spiritual needs. The results indicated that active presence, empathetic care, non-verbal communication, and individualized conversations were important for identifying and addressing spiritual needs. At the same time, lack of time and staff, insufficient knowledge, and the absence of clear guidelines made it difficult to integrate spiritual care into nurses’ clinical practice. Conclusion: Spiritual care is an important part of palliative care and can contribute to security, meaning, and dignity for patients receiving end-of-life care. To strengthen nurses’ ability to meet patients’ spiritual needs, increased knowledge, improved organizational conditions, and the development of clear structures and guidelines are required. The study also highlights the importance of integrating spiritual needs as part of equitable and person-centered care.