Background: Female genital mutilation, FGM, is an ancient custom often regarded as a rite of passage. Over 230 million girls and women have undergone FGM, which primarily occurs in the Middle East, North Africa, and Asia. FGM is most often practiced when the girl is newborn up to 15 years old and is considered normal in the countries where it occurs. The tradition lacks medical purposes, which violates human rights.

Aim: The aim was to investigate nurses' experiences in interacting with women who have undergone FGM.

Method: The method was a general literature review in which articles with a qualitative approach were collected from the databases CINAHL and PubMed.

Results: Two main themes emerged: “Dynamics and challenges of the care relationship” and “Support and development for healthcare staff” and three subthemes: “Communication and interaction”, “Patient centered care and transcultural understanding” and “emotional and personal challenges in the care relationship”.

Conclusion: Lack of cultural competence and communication among nurses in developed countries negatively impacts healthcare, creating fear, prejudice, and ethnocentric thinking. This can lead to complications in care and deteriorated relationships with patients. There is a need for education and clearer guidelines on how to approach women who have undergone FGM.